Compare prices and buy N-Acetyl Semax from 4 research peptide vendors - also called suppliers or sources. Updated daily.
A modified form of the heptapeptide Semax carrying an N-terminal acetyl group and a C-terminal amide (N-acetyl Semax amidate, CAS 2920938-90-3). The end caps are meant to slow breakdown by the enzymes that trim peptides from either end. Published work on the acetylated form is limited to laboratory chemistry and cell studies, so vendor descriptions of its activity draw on research into parent Semax. Not FDA-approved.
For research purposes only. Not medical advice.
N-acetyl Semax amidate is Semax with both ends of its seven-residue chain capped. An acetyl group sits on the amino group of the N-terminal methionine, and the C-terminal proline ends in an amide instead of a carboxylic acid, giving Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH2. PubChem's compound record, created in December 2024, gives the formula C39H54N10O10S and a molecular weight of 855.0, about 41 daltons above Semax's, and lists "N-acetyl semax" as a synonym of the amidated structure. PubChem links no published literature to the record.
Searches found two laboratory papers on Semax with an acetylated N-terminus.
Shevchenko and colleagues at the Russian Academy of Sciences' Institute of Molecular Genetics reported on the stability of acetylated Semax to proteolysis in various biological media in Doklady Biological Sciences in 2013. PubMed carries no abstract for the paper, and its subject indexing lists rats, brain, microsomes and leucine aminopeptidase.
Magrì and colleagues at Italy's National Research Council and the University of Catania compared Semax with its N-acetylated form in the Journal of Inorganic Biochemistry in 2016. Acetylation changed the main copper(II) complex the peptide forms at physiological pH. In SH-SY5Y neuroblastoma cells the acetylated peptide did not protect against copper-induced toxicity, which the authors attributed to the role of Semax's free N-terminal amino group in that protection. Both peptides formed zinc(II) complexes of comparable strength, and acetylation did not affect zinc entry into the cells.
Both papers name the peptide by its N-terminal acetylation. Neither title, nor the 2016 abstract, mentions a C-terminal amide, so they do not say whether the amidated form indexed here was the one tested.
As of October 21, 2026, PubMed returns no record for the phrase "N-acetyl Semax", Europe PMC returns no paper for "N-acetyl Semax" or "Semax amidate", and ClinicalTrials.gov lists no study under N-acetyl Semax, Semax amidate or NA-Semax. No study in humans was found.
As of October 21, 2026, N-acetyl Semax amidate holds no FDA approval, and none of these sources names it or any other acetylated form of Semax.
Semax's own compounding record is on the Semax page, and the FDA documents behind it name unmodified Semax. The July 2026 agenda listed the substances under review as Semax (free base) and Semax acetate. PubChem records Semax acetate as unmodified Semax paired with acetic acid, a salt, so it is a different substance from the N-acetylated peptide despite the similar name.
No. Semax acetate is a salt, the unmodified Semax heptapeptide paired with acetic acid, which PubChem records as a two-component substance. N-Acetyl Semax Amidate is a modified peptide, with an acetyl group bonded to the N-terminal methionine and an amide at the C-terminal proline, and PubChem gives it the formula C39H54N10O10S. The name Semax acetate therefore describes a salt form of plain Semax, not the acetylated peptide. PeptideScouter indexes plain Semax and N-Acetyl Semax as separate rows.
No human study was found. As of October 21, 2026 ClinicalTrials.gov lists no registered study under N-acetyl Semax, Semax amidate or NA-Semax. The published work found on the acetylated peptide is laboratory research: a 2013 paper from the Russian Academy of Sciences' Institute of Molecular Genetics on its stability to proteolysis in biological media, and a 2016 paper in the Journal of Inorganic Biochemistry on its copper and zinc binding and its effect on copper toxicity in neuroblastoma cells. Neither paper's title mentions a C-terminal amide, so it is not clear that either tested the amidated form sold under this name.
No. As of October 21, 2026 drugsfda returns no application under the name Semax, and no acetylated Semax appears on FDA's Category 2 page of bulk drug substances that may present significant safety risks, on the 503A nominations list updated May 14, 2026, or on the 503B nominations list updated March 21, 2025. The Pharmacy Compounding Advisory Committee's minutes for October and December 2024 and its July 2026 agenda do not name it. The July 2026 committee review of Semax covered Semax free base and Semax acetate, not the N-acetylated peptide.
PeptideScouter computes a per-milligram price only for vials whose size is stated in milligrams. A nasal spray is a solution sold by the bottle, so it appears in the price table at its package price but stays out of every per-milligram comparison on this page. A spray's price also covers the liquid and the pump, so dividing it by the stated peptide content would not compare like for like with a vial.
N-Acetyl Semax is sold by 4 research peptide vendors indexed on PeptideScouter, with 6 tracked listings compared per vendor in the table above. Pricing is normalized and refreshed daily.
All 4 indexed research peptide vendors currently have N-Acetyl Semax in stock. Stock state is refreshed daily from each vendor's catalog.
Platinum Lion Peptides currently lists N-Acetyl Semax at $2.33/mg, the lowest listed price across 4 tracked research peptide vendors. With current vendor discount codes applied, the lowest effective price is $2.10/mg.
Discount codes are issued per vendor rather than per peptide, so any code applies across that vendor's whole catalog. All 4 vendors listing N-Acetyl Semax publish a PeptideScouter code, worth 10% to 15% off. Applied, the lowest effective price falls from $2.33/mg listed to $2.10/mg at Platinum Lion Peptides. Each vendor's code is shown beside its price in the table above.
N-Acetyl Semax ranges from $2.33/mg to $4.90/mg across 6 listings from 4 research peptide vendors, normalized to USD per milligram and refreshed daily.
4 research peptide vendors currently list N-Acetyl Semax on PeptideScouter. We track 6 listings across size and kit variants.
N-Acetyl Semax's CAS Registry Number is 2920938-90-3. It is also sold as Semax (N-Acetyl), NA Semax Amidate, NA-Semax.
