LIVE
A 7-amino-acid shortened analog (CAS 1801959-12-5) of the 17-residue natural peptide spadin, optimized for TREK-1 potassium channel inhibition with improved metabolic stability (IC50 ~0.12 nM on TREK-1). TREK-1 blockade recapitulates the rapid-onset antidepressant mechanism of conventional SSRIs without their 2-3 week delay; promotes hippocampal neurogenesis in rodent depression models. Preclinical candidate; not FDA-approved.
For research purposes only. Not medical advice.
Ruo Bio currently lists PE-22-28 at $3.80/mg, the lowest indexed price across 5 tracked research peptide vendors.
PE-22-28 ranges from $3.80/mg to $13.00/mg across 7 listings from 5 research peptide vendors, normalized to USD per milligram and refreshed daily.
5 research peptide vendors currently list PE-22-28 on PeptideScouter. We track 7 active listings across size and kit variants.
PE-22-28's CAS Registry Number is 1801959-12-5.
