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A 16-amino-acid mitochondrial-derived peptide (CAS 1627580-64-6) encoded in a small open reading frame within the 12S ribosomal RNA gene (MT-RNR1). Translocates to the nucleus under metabolic stress to regulate adaptive transcription; increases AMPK activity, enhances glucose uptake, and protects against diet-induced obesity and insulin resistance in rodent models. Discovered by the Pinchas Cohen lab at USC and reported in Cell Metabolism in 2015; circulating levels decline with age and are reduced in type 2 diabetes. Preclinical-stage.
For research purposes only. Not medical advice.
Step One currently lists MOTS-C at $1.88/mg, the lowest indexed price across 22 tracked research peptide vendors.
MOTS-C ranges from $1.72/mg to $6.60/mg across 37 listings from 22 research peptide vendors, normalized to USD per milligram and refreshed daily.
22 research peptide vendors currently list MOTS-C on PeptideScouter, with 16 in stock right now. We track 37 active listings across size and kit variants.
MOTS-C's CAS Registry Number is 1627580-64-6. It is also sold as MOT-C.
