A 21- or 24-amino-acid mitochondrial-derived peptide (CAS 330936-69-1) encoded in a small open reading frame within the 16S ribosomal RNA gene (MT-RNR2) of mitochondrial DNA. Discovered in 2001 via cDNA screening of surviving neurons in Alzheimer's disease brain; the prototype of the mitochondrial-derived peptide class (which also includes MOTS-c and SHLP1-6). Cytoprotective, anti-apoptotic, and insulin-sensitizing activity demonstrated preclinically in models of Alzheimer's disease, ischemia, and metabolic dysfunction. Circulating levels decline with age.
For research purposes only. Not medical advice.
Ruo Bio currently lists Humanin at $4.60/mg (currently out of stock), the lowest indexed price across 1 tracked research peptide vendor.
1 research peptide vendor currently lists Humanin on PeptideScouter. We track 1 active listing across size and kit variants.
Humanin's CAS Registry Number is 330936-69-1.