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A synthetic tetrapeptide (D-Arg-2',6'-dimethylTyr-Lys-Phe-NH2 / elamipretide, CAS 736992-21-5) that accumulates 1000-fold in the inner mitochondrial membrane by binding cardiolipin — the signature lipid of the inner membrane. Stabilizes cardiolipin-protein interactions essential for cristae architecture and respiratory-chain supercomplex assembly, preserving ATP synthesis and reducing reactive oxygen species. FDA-approved on September 19, 2025 by Stealth BioTherapeutics as FORZINITY for improving muscle strength in adult and pediatric Barth syndrome patients (>=30 kg) — the first FDA-approved mitochondria-targeted therapy. Additional Phase 2/3 programs ongoing in dry age-related macular degeneration and primary mitochondrial myopathy.
For research purposes only. Not medical advice.
Step One currently lists SS-31 at $1.98/mg, the lowest indexed price across 15 tracked research peptide vendors.
SS-31 ranges from $1.98/mg to $7.50/mg across 24 listings from 15 research peptide vendors, normalized to USD per milligram and refreshed daily.
15 research peptide vendors currently list SS-31 on PeptideScouter, with 10 in stock right now. We track 24 active listings across size and kit variants.
SS-31's CAS Registry Number is 736992-21-5. It is also sold as MTP-131, S-31-S, MTT-31.
