A synthetic tripeptide (Lys-Pro-Val, CAS 67727-97-3) corresponding to the three C-terminal amino acids (residues 11-13) of alpha-melanocyte-stimulating hormone. Despite its alpha-MSH origin, KPV's anti-inflammatory activity is not melanocortin-receptor-mediated — it enters intestinal and immune cells via the PepT1 oligopeptide transporter and suppresses NF-kB activation, reducing downstream pro-inflammatory cytokine synthesis. Studied preclinically in DSS-induced colitis, inflammatory skin conditions, and allergic-asthma models. Not FDA-approved.
For research purposes only. Not medical advice.
Sunrise Bioresearch currently lists KPV at $2.60/mg, the lowest indexed price across 20 tracked research peptide vendors.
KPV ranges from $2.60/mg to $8.00/mg across 24 listings from 20 research peptide vendors, normalized to USD per milligram and refreshed daily.
20 research peptide vendors currently list KPV on PeptideScouter, with 19 in stock right now. We track 24 active listings across size and kit variants.
KPV's CAS Registry Number is 67727-97-3.